发给老马备查:$ L- g- |+ }$ C+ i
滴水察海(69304838) 15:23:23
7 u7 f3 f9 E% S& _% y V" T, l, H7 E老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
& {2 A) {; v. M& |1 k) k吉非替尼和S-1连用的依据9 r* r' O0 {2 I6 s/ }' g5 r
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
P; W1 z) u% }2 ?+ [: Z& J是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达9 C, `0 D2 [/ X4 m) O
这样是不是推理出,耐药后,可以用S-1和培美了?+ w3 s" l$ t6 c' C4 b
结论:8 B g4 i, l: o) o8 c1 @
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |