发给老马备查:( I( }3 w% e- G: n, m L- w" M
滴水察海(69304838) 15:23:23( ]! {( i# K" t& u# W; f: j
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱: C/ K, B: Z$ x8 u( y5 \! `( Y5 L
吉非替尼和S-1连用的依据
$ L: Y' E5 h1 ?, ^3 H1 D# H, OGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
1 }( q7 _ C, k/ y0 S2 T$ `是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达# T+ Y8 s. @) b3 n+ U
这样是不是推理出,耐药后,可以用S-1和培美了?8 E7 {$ o# B: ]" o, {
结论:
0 i* \5 s! x2 h' [4 z如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |